%0 Journal Article
%T Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell Fate
%J Biomimetics | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/biomimetics4020043
%X Extracellular matrix remodeling plays a pivotal role during mesenchyme patterning into different lineages. Tension exerted from cell membrane receptors bound to extracellular matrix ligands is transmitted by the cytoskeleton to the cell nucleus inducing gene expression. Here, we used dendrimer-based arginine¨Cglycine¨Caspartic acid (RGD) uneven nanopatterns, which allow the control of local surface adhesiveness at the nanoscale, to unveil the adhesive requirements of mesenchymal tenogenic and osteogenic commitments. Cell response was found to depend on the tension resulting from cell¨Csubstrate interactions, which affects nuclear morphology and is regulated by focal adhesion size and distribution. View Full-Tex
%U https://www.mdpi.com/2313-7673/4/2/43