%0 Journal Article
%T Facile Preparation of Fe3O4/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan
%J Biomolecules | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/biom9060245
%X In this study, we reported facile synthesis of Fe 3O 4/C composite and its application for the cost-effective and sensitive determination of tryptophan (Trp) in human serum samples. Fe 3O 4/C composites were prepared by a simple one-pot hydrothermal method followed by a mild calcination procedure, using FeCl 3£¿6H 2O as Fe 3O 4 precursor, and glucose as reducing agent and carbon source simultaneously. The Fe 3O 4/C composite modified glassy carbon electrode (Fe 3O 4/C/GCE) was prepared by drop-casting method. The microstructure and morphology of Fe 3O 4/C composite was characterized by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Due to large specific surface area and synergistic effect from Fe 3O 4 nanoparticles and carbon coating, Fe 3O 4/C composite showed excellent electrocatalytic activity toward the oxidation of Trp. As a result, the proposed Fe 3O 4/C/GCE displayed superior analytical performances toward Trp determination, with two wide detection ranges (1.0¨C80 ¦ÌM and 80¨C800 ¦ÌM) and a low detection limit (0.26 ¦ÌM, S/N = 3). Moreover, successful detection of Trp in human serum samples further validate the practicability of the proposed sensor. View Full-Tex
%U https://www.mdpi.com/2218-273X/9/6/245