%0 Journal Article
%T Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues
%J Cells | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/cells8111373
%X The Nr4a family of nuclear hormone receptors is composed of three members¡ªNr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization
%U https://www.mdpi.com/2073-4409/8/11/1373