%0 Journal Article
%T Synthesis of Imidazo[1,2-a]pyridines via Multicomponent GBBR Using ¦Á-isocyanoacetamides£¿
%J Proceedings | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/ecsoc-22-05692
%X Six novel imidazo[1,2- a]pyridines were synthesized by Groebke¨CBlackburn¨CBienayme£¿ reactions (GBBRs) under eco-friendly conditions (10 mol% ammonium chloride catalyst in EtOH at room temperature) with moderate to good yields (76¨C44%) using 2-isocyano-1-morpholino-3-phenylpropan-1-one. This is the first successful use of this type of ¦Á-isocyanoacetamide in a GBBR, as these reactive isonitriles readily undergo ring-chain tautomerization, as reported in other IMCRs (isonitrile-based multicomponent reactions). The product structures contain a peptidomimetic imidazo[1,2- a]pyridine scaffold linked to an ¦Á-aminomorpholide and are of interest to medicinal chemists
%U https://www.mdpi.com/2504-3900/9/1/53