%0 Journal Article
%T A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows
%J Veterinary Sciences | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/vetsci6030073
%X The dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally versus subcutaneously administered meloxicam in early-lactation dairy cattle. The study was conducted at a commercial dairy herd in southwestern Ontario, Canada. Twelve postpartum cows were enrolled in the study, receiving either subcutaneous meloxicam (MET) at 0.5 mg/kg body weight (n = 6) or oral meloxicam (MOS) at a higher dose of 1.0 mg/kg body weight (n = 6) immediately following parturition. The predicted half-life (12.5 ¡À 2.0 vs. 28.5 ¡À 2.0 h), C max (1.59 ¡À 0.15 vs. 1.95 ¡À 0.16 ¦Ìg/mL), T max (5.33 vs. 11.7 h), and AUC 0¡ú¡Þ (39.6 ¡À 7.4 vs. 115.6 ¡À 19 h * ¦Ìg/mL) differed significantly between MET and MOS cows, respectively. After controlling for the treatment group, first lactation cows had a significantly higher half-life (4.1 ¡À 2.1 h), C max (0.56 ¡À 0.2 ¦Ìg/mL), and AUC 0¡ú¡Þ (21.6 ¡À h * ¦Ìg/mL) relative to second lactation or greater cows, respectively. Administration of meloxicam through the subcutaneous or oral route results in appreciable, dose-dependent systemic levels. View Full-Tex
%U https://www.mdpi.com/2306-7381/6/3/73