%0 Journal Article
%T Lutathera£¿: The First FDA- and EMA-Approved Radiopharmaceutical for Peptide Receptor Radionuclide Therapy
%J Pharmaceuticals | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/ph12030114
%X As the first radiopharmaceutical for Peptide Receptor Radionuclide Therapy (PRRT), Lutathera £¿ was approved by the EMA in 2017 and the FDA in 2018 for the treatment of somatostatin receptor (SSTR) positive gastroenteropancreatic neuroendocrine tumors. Using the concept of PRRT, Lutathera £¿ combines the radionuclide 177Lu with the somatostatin analogue DOTA-TATE, thus delivering ionizing radiation specifically to tumor cells expressing somatostatin receptors. As a result, DNA single- and double-strand breaks are provoked, in case of double-strand breaks leading to cell death of the tumor and its SSTR-positive lesions. View Full-Tex
%U https://www.mdpi.com/1424-8247/12/3/114