%0 Journal Article
%T A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita
%J Nanomaterials | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/nano9020309
%X In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)¡ªsilver nanoparticles (AgNPs, 40 ¡À 6 nm), nickel (NiNPs, 43 ¡À 6 nm), cobalt oxide (Co 3O 4NPs, 60 ¡À 6 nm), and chromium oxide (Cr 3O 4NPs, 50 ¡À 5 nm)¡ªon freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co 3O 4NPs was discerned while a low survival rate in the case of Cr 3O 4NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr 3O 4NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co 3O 4NP-, and Cr 3O 4NP-treated groups. An upgrading in albumin level was witnessed in Co 3O 4NP- and Cr 3O 4NP-treated groups while a high level of globulin was noted in NiNP- and Co 3O 4NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed. View Full-Tex
%U https://www.mdpi.com/2079-4991/9/2/309