%0 Journal Article
%T Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury
%A Daisuke Nojima
%A Gen Inoue
%A Gou Kubota
%A Hirohito Kanamoto
%A Jun Sato
%A Junichi Nakamura
%A Kazuhide Inage
%A Kazuhisa Takahashi
%A Kazuki Fujimoto
%A Kazuki Kuniyoshi
%A Kazuyo Yamauchi
%A Koki Abe
%A Masayuki Miyagi
%A Miyako Suzuki
%A Nobuyasu Ochiai
%A Seiji Ohtori
%A Sumihisa Orita
%A Takeshi Sainoh
%A Yasuchika Aoki
%A Yasuhiro Shiga
%A Yawara Eguchi
%A Yoshihiro Sakuma
%J Archive of "Yonsei Medical Journal".
%D 2016
%R 10.3349/ymj.2016.57.3.748
%X The pathophysiology of discogenic low back pain is not fully understood. Tetrodotoxin-sensitive voltage-gated sodium (NaV) channels are associated with primary sensory nerve transmission, and the NaV1.7 channel has emerged as an analgesic target. Previously, we found increased NaV1.7 expression in dorsal root ganglion (DRG) neurons innervating injured discs. This study aimed to examine the effect of blocking NaV1.7 on sensory nerves after disc injury
%K Low back pain
%K NaV1.7
%K intervertebral disc
%K CGRP
%K rat
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800367/