%0 Journal Article
%T Activation of NF-百B and AP-1 Mediates Hyperproliferation by Inducing 汕-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
%A Bohye Park
%A Eunyoung Byun
%A Hyeyoung Kim
%A Joo Weon Lim
%J Archive of "Yonsei Medical Journal".
%D 2016
%R 10.3349/ymj.2016.57.3.647
%X In the gastric mucosa of Helicobacter pylori (H. pylori)-infected patients with gastritis or adenocarcinoma, proliferation of gastric epithelial cells is increased. Hyperproliferation is related to induction of oncogenes, such as 汕-catenin and c-myc. Even though transcription factors NF-百B and AP-1 are activated in H. pylori-infected cells, whether NF-百B or AP-1 regulates the expression of 汕-catenein or c-myc in H. pylori-infected cells has not been clarified. The present study was undertaken to investigate whether H. pylori-induced activation of NF-百B and AP-1 mediates the expression of oncogenes and hyperproliferation of gastric epithelial cells
%K Helicobacter pylori
%K NF-百B
%K AP-1
%K oncogenes
%K hyperproliferation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800354/