%0 Journal Article
%T Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
%A Chae-Ok Yun
%A Dong Kyun Rah
%A Eunhye Kang
%A Hyo Min Ahn
%A In Sik Yun
%A Tai Suk Roh
%A Won Jai Lee
%A Yong Oock Kim
%J Archive of "Yonsei Medical Journal".
%D 2019
%R 10.3349/ymj.2019.60.9.854
%X Relaxin (RLX) is a transforming growth factor-¦Â1 (TGF-¦Â1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads) are accepted vectors for cancer gene therapy. However, repeated treatments of Ad are limited by short-term biological activity in vivo. The efficacy of sustained RLX expression to scar remodeling was assessed using an injectable alginate gel-matrix system
%K Gene therapy
%K scar remodeling
%K relaxin
%K adenovirus
%K alginate gel
%K pig scar model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704020/