%0 Journal Article
%T Predicting Treatment Response of Breast Cancer to Neoadjuvant Chemotherapy Using Ultrasound-Guided Diffuse Optical Tomography
%A Aiyu Miao
%A Cai Chang
%A Guangyu Liu
%A Jin Zhou
%A Li Xie
%A Wenxiang Zhi
%A Xiaoli Zhu
%J Archive of "Translational Oncology".
%D 2018
%R 10.1016/j.tranon.2017.10.011
%X PURPOSE: To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS: Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre¨C and post¨Clast chemotherapy, size and total hemoglobin concentration (THC) of each lesion were measured by conventional US and US-guided DOT 1 day before biopsy (time point t0, THC THC0, SIZE S0) and 1 to 2 days before surgery (time point tL, THCL, SL). The relative changes in THC and SIZE of lesions after the first and last NAC cycles were considered as the variables ¦¤THC and ¦¤SIZE. Receiver operating characteristic curve was performed to calculate ¦¤THC and ¦¤SIZE cutoff values to evaluate pathologic response of 93 breast cancers to NAC, which were then prospectively used to predicate response of 61 breast cancers to NAC. RESULTS: The cutoff values of ¦¤THC and ¦¤SIZE for evaluation of breast cancers NAC treatment response were 23.9% and 42.6%. At ¦¤THC 23.9%, the predicted treatment response in 61 breast lesions for the time points t1 to t3 was calculated by area under the curve (AUC), which were AUC1 0.534 (P = .6668), AUC2 0.604 (P = .1893), and AUC3 0.674(P =. 0.027), respectively; for ¦¤SIZE 42.6%, at time points t1 to t3, AUC1 0.505 (P = .9121), AUC2 0.645 (P = .0115), and AUC3 0.719 (P = .0018). CONCLUSION: US-guided DOT ¦¤THC 23.9% and US ¦¤SIZE 42.6% can be used for the response evaluation and earlier prediction of the pathological response after three rounds of chemotherapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714257/