%0 Journal Article
%T Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4)
%A Anke C. Fender
%A Anne Bertling
%A Beate E. Kehrel
%A Janina Treffon
%A Martin F. Brodde
%A Mayken Visser
%A Michelle Fennen
%A Reinhard Kelsch
%J Archive of "Transfusion Medicine and Hemotherapy".
%D 2017
%R 10.1159/000472157
%X Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity through enzymatic degradation of heme and transcription of antioxidant genes. Plasma-derived factor concentrates contain many proteins that might impact on cellular pathways in joints, blood, and vessels
%K Hemophilia A
%K Factor VIII
%K Platelets
%K Macrophages
%K Scavenger receptors
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649264/