%0 Journal Article
%T The role of Slit-Robo signaling in the regulation of tissue barriers
%A Chen-Yi Liao
%A Jinghua Tsai Chang
%A Ling-Yi Wang
%A Ming-Fang Wu
%J Archive of "Tissue Barriers".
%D 2017
%R 10.1080/21688370.2017.1331155
%X The role of Slit/Robo signaling has extended from initial axon repulsion in the developing nervous system to organ morphogenesis, cancer development and angiogenesis. Slit/Robo signaling regulates similar pathways within these processes. Slit/Robo ensures the homeostasis of the dynamic interaction between cell-cell and cell-matrix interactions. The dysregulation of Slit/Robo signaling damages the tissue barrier, resulting in developmental abnormalities or disease. Here, we summarize how Slit/Robo controls kidney morphogenesis and describe the dual roles of Slit/Robo signaling in the regulation of tumorigenesis and angiogenesis
%K alternative splicing
%K angiogenesis
%K blood vessel stability
%K cancer cell migration
%K cell-cell interaction
%K endothelial cell permeability
%K kidney development
%K Slit/Robo signaling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501134/