%0 Journal Article
%T In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test
%A Christian von Heymann
%A Elisabeth Langer
%A Klaus-Dieter Wernecke
%A Mareike Kristina K£¿rber
%A Martin K£¿hr
%A Wolfgang Korte
%J Archive of "Transfusion Medicine and Hemotherapy".
%D 2017
%R 10.1159/000470622
%X An increasing number of oral anticoagulants has been approved, including dabigatran etexilate (DE). DE is a direct thrombin inhibitor that requires no routine monitoring, but, if necessary (e.g. urgent surgery etc.), the diluted thrombin time measured with Hemoclot£¿ has shown reliable results. So far, no point-of-care (PoC) assay is available to measure DE effects. The EcaTEM assay uses ecarin to initiate the coagulation cascade at the step of thrombin generation and measures the clotting time (CT) by thromboelastometry
%K Dabigatran
%K Hemorrhage
%K Coagulation measurement
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425765/