%0 Journal Article
%T EGFR Inhibition in a Pretreated Sacral Chordoma: A Role for Erlotinib? Case Report and a Brief Review of Literature
%A D. Trapani
%A F. Conforti
%A T. De Pas
%J Archive of "Translational Medicine @ UniSa".
%D 2017
%X We describe the case of a 69-year old male with an EGFR- positive Imatinib refractory sacral chordoma with synchronous lung metastases, treated with erlotinib, a first-generation EGFR inhibitor. After disease progression following first-line Imatinib and a combination therapy with everolimus plus metformin, we made a challenge with an EGFR tyrosine kinase inhibitor (EGFR TKI), erlotinib. Despite a brief clinical benefit, the patient presented a rapid clinical deterioration leading to death, after 8 weeks of treatment
%K chordoma
%K erlotinib
%K Imatinib refractory
%K sacral tumor
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536160/