%0 Journal Article
%T Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases
%A Dorothea M. Heuberger
%A Reto A. Schuepbach
%J Archive of "Thrombosis Journal".
%D 2019
%R 10.1186/s12959-019-0194-8
%X Mechanisms of PAR activation. PAR activation is regulated by a direct proteolytic cleavage at the N-terminus, b homo- or heterodimerization with other PARs and transactivation through the cleaved tethered ligand, c compartmentalization on the cell surface, d degradation or recycling by endosomal trafficking, e posttranslational modifications such as glycosylation, phosphorylation, and ubiquitination, and f co-localization with other receptors and cofactor
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440139/