%0 Journal Article
%T Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study
%A Anthonie W. A. Lensing
%A Dagmar Kubitza
%A Jan Stampfuss
%A J£¿rg Lippert
%A Katrin Coboeken
%A Kirstin Thelen
%A Matthias Frede
%A Rolf Burghaus
%A Stefan Willmann
%A Wolfgang M¨¹ck
%J Archive of "Thrombosis Journal".
%D 2018
%R 10.1186/s12959-018-0185-1
%X a Staggered approach and sampling strategy for collecting PK/PD and safety data in pediatric cohorts in this phase I study. PK/PD and safety data available for at least four subjects before starting next cohort; blue arrows indicate data monitoring committee agreement to progress to the next planned step of the phase I study, i.e. data collection for the next cohort. b Sampling windows per age group eq., equivalent, PD pharmacodynamics, PK pharmacokinetics
%K Pediatric
%K Pharmacokinetics
%K Physiologically based pharmacokinetic modelling
%K Rivaroxaban
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278136/