%0 Journal Article
%T The adhesion GPCR latrophilin ¨C a novel signaling cascade in oriented cell division and anterior-posterior polarity
%A Jana Winkler
%A Simone Pr£żmel
%J Archive of "Worm".
%D 2016
%R 10.1080/21624054.2016.1170274
%X Although several signaling pathways in oriented cell division have been well characterized such as delta/notch inductions or wnt/frizzled-based anterior-posterior polarity, there is strong evidence for additional signal pathways controlling early anterior-posterior polarity decisions. The homolog of the adhesion G protein-coupled receptor latrophilin, LAT-1 has been identified as a receptor essential for oriented cell division in an anterior-posterior direction of specific blastomeres in the early C. elegans embryo. We recently conducted a study aiming at clarifying the signals involved in LAT-1 function. We identified a Gs protein/adenylyl cyclase/cAMP pathway in vitro and demonstrated its physiological relevance in oriented cell division. By interaction with a Gs protein LAT-1 elevates cAMP levels. These data indicate that G-protein signaling in oriented cell division is not solely GPCR-independent. This commentary will discuss our findings in the context of the current knowledge of mechanisms controlling oriented cell division and anterior-posterior polarity. Further, we identify open questions which need to be addressed in the future
%K early C. elegans embryo
%K G protein-coupled receptor
%K latrophilin
%K signaling pathway
%K spindle orientation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911996/