%0 Journal Article
%T Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells
%A Byung Sun Yoo
%A Han Bit Kim
%J Archive of "Toxicological Research".
%D 2016
%R 10.5487/TR.2016.32.3.239
%X Propolis is a multicomponent, active, complex resinous substance collected by honeybees from a variety of plant sources. We have studied the effect of propolis on neurite outgrowth of SH-SY5Y human neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA). Propolis, at a concentration of 3 ¦Ìg/mL, had no significant effect on the viability of differentiating SH-SY5Y cells. However, the neurite outgrowth of the differentiating SH-SY5Y cells treated with propolis (0.3~3 ¦Ìg/mL) for 48 hr was significantly inhibited in a dose-dependent manner. Treatment of RA-stimulated differentiating SH-SY5Y cells with 0.3 to 3 ¦Ìg/mL propolis resulted in decreased level of transglutaminase and 43-kDa growth-associated protein (GAP-43) in a dose-dependent manner. The results indicate that propolis is able to inhibit neurite outgrowth of differentiating SH-SY5Y cells
%K Propolis
%K SH-SY5Y neuroblastoma cell
%K Neurite outgrowth
%K TGase
%K GAP-43
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946423/