%0 Journal Article
%T External Application of Apo-9กไ-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis
%A Eun-Sook Yoo
%A Hee-Kyoung Kang
%A Jin-Won Hyun
%A Mi-Hee Ko
%A Min-Chull Na
%A Na-Jin Kang
%A Nam-Ho Lee
%A Sang-Chul Han
%A Sejin Kim
%A Weon-Jong Yoon
%A Young-Sang Koh
%J Archive of "Toxicological Research".
%D 2016
%R 10.5487/TR.2016.32.2.109
%X Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9กไ-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9กไ-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9กไ-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9กไ-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9กไ-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9กไ-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases
%K Apo-9กไ-fucoxanthinone
%K Atopic dermatitis
%K 2
%K 4-Dinitrochlorobenzene
%K Immunoglobulin E
%K Phorbol 12-myristate 13-acetate
%K Ionomycin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843979/