%0 Journal Article
%T The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
%A Jian-fang Ma
%A Xue-mei Qi
%J Archive of "Translational Neurodegeneration".
%D 2017
%R 10.1186/s40035-017-0091-7
%X A¦Â can be transported bi-directionally through BBB by multiple receptors. In normal conditions the transportation of A¦Â can be mediated by multiple receptors in endothelium. After binding to ApoE or ¦Á2M (¦Á2-microglobulin) A¦Â can be transported by LRP1 or it can be transported by LRP2 after binding to ApoJ (clusterin). Some other receptors also mediate A¦Â efflux, such as ABC transporter, insulin-sensitive transporter and ANP-sensitive transporter. There¡¯s only little A¦Â influx mediated by RAGE and OATP. In addition A¦Â can be transported to perivascular spaces and eliminated through perivascular drainage. In CAA pathological condition, there¡¯s a change in the transporter profile of the BBB, with the efflux receptors decreasing and the influx receptors increasing, leading to the decrease of A¦Â clearance and its deposition on the vessel wall. Consequently components changes of cerebrovascular basement membrane as well as the weakness of perivascular drainage results in the aggregation of A¦Â in blood vessels aggregating CA
%K Cerebral amyloid angiopathy
%K Alzheimer¡¯s disease
%K Amyloid ¦Â-protein
%K Clearance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559841/