%0 Journal Article
%T A Novel Phospholipase A2 Isolated from Palythoa caribaeorum Possesses Neurotoxic Activity
%A Abel Santamar¨ªa
%A Ana Laura Col¨ªn-Gonz¨¢lez
%A Benjam¨ªn Velasco-Bejarano
%A Fernando Lazcano-P¨¦rez
%A Jaime Marcial-Quino
%A Karen Helena D¨ªaz de la Vega-Casta£¿eda
%A Miguel Cuevas-Cruz
%A Norma A. Valdez-Cruz
%A Roberto Arregu¨ªn-Espinosa
%A Sa¨²l G¨®mez-Manzo
%A Sergio A. Rom¨¢n-Gonz¨¢lez
%A Ulises Hern¨¢ndez-Guzm¨¢n
%J Archive of "Toxins".
%D 2019
%R 10.3390/toxins11020089
%X Zoanthids of the genus Palythoa are distributed worldwide in shallow waters around coral reefs. Like all cnidarians, they possess nematocysts that contain a large diversity of toxins that paralyze their prey. This work was aimed at isolating and functionally characterizing a cnidarian neurotoxic phospholipase named A2-PLTX-Pcb1a for the first time. This phospholipase was isolated from the venomous extract of the zoanthid Palythoa caribaeorum. This enzyme, which is Ca2+-dependent, is a 149 amino acid residue protein. The analysis of the A2-PLTX-Pcb1a sequence showed neurotoxic domain similitude with other neurotoxic sPLA2¡äs, but a different catalytic histidine domain. This is remarkable, since A2-PLTX-Pcb1a displays properties like those of other known PLA2 enzymes
%K cnidaria
%K venom
%K phospholipase A2
%K neurotoxin
%K Palythoa caribaeorum
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409743/