%0 Journal Article %T Treatment of voluminous and complicated superficial slow-flow vascular malformations with sirolimus (PERFORMUS): protocol for a multicenter phase 2 trial with a randomized observational-phase design %A Annabel Maruani %A Anne le Touze %A Annie-Pierre Jonville-Bera %A Baptiste Morel %A Bruno Giraudeau %A Catherine Droitcourt %A Christine Chiaverini %A Denis Herbreteau %A Didier Bessis %A Dominique Goga %A Elsa Tavernier %A Groupe de Recherche de la Societ¨¦ Fran£¿aise de Dermatologie P¨¦diatrique %A G¨¦rard Lorette %A Jean-Baptiste Woillard %A Juliette Mazereeuw-Hautier %A J¨¦rome Rollin %A Laurent Guibaud %A Ludovic Martin %A Olivia Boccara %A Pierre Vabres %A Sophie Blaise %A Sophie Leducq %A St¨¦phanie Mallet %A S¨¦bastien Barbarot %A Val¨¦rie Gissot %A Yves Gruel %J Archive of "Trials". %D 2018 %R 10.1186/s13063-018-2725-1 %K Vascular anomalies %K Lymphatic malformations %K Venous malformations %K Children %K Sirolimus %K Mammalian target of rapamycin inhibitors %K Randomized placebo-phase design %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020321/