%0 Journal Article
%T Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders
%A Anu J£¿rv
%A Christine B£¿le-Feysot
%A Jaanus Harro
%A Jonathan Breton
%A Kirsti Akkermann
%A Mo£¿se Co£¿ffier
%A Nicolas Lucas
%A Pierre D¨¦chelotte
%A Romain Legrand
%A Sergue£¿ O. Fetissov
%J Archive of "Translational Psychiatry".
%D 2019
%R 10.1038/s41398-019-0422-9
%X a Dissociation equilibrium constants (KD). b Association rates (ka). c Dissociation rates (kd). d¨Ch Representative sensorgrams illustrating different affinity kinetics of IgG binding to ¦Á-MSH in surface plasmon resonance units (RU) from each study group: d Ctrl (n£¿=£¿65), e obese (n£¿=£¿17), f anorexia nervosa (n£¿=£¿28), g bulimia nervosa (n£¿=£¿34), and h binge eating disorder (n£¿=£¿14). IgG concentrations, 3360£¿nM (in pink), 1680 nM (in red), 840£¿nM (in blue), 420£¿nM (in grey), 210£¿nM (in green). Fitting with the Langmuir¡¯s 1:1 model. i Relative to controls plasma levels of ¦Á-MSH-reactive IgG after their extraction from plasma. Data are means£¿¡À£¿s.e.m. Kruskal¨CWallis test with Dunns¡¯ post-tests, ***p£¿<£¿0.001, **p£¿<£¿0.01, *p£¿<£¿0.05 (b, c, i) or analysis of variance with Tukey¡¯s post-test, $$$p£¿<£¿0.001 vs. Ctrl (i
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372612/