%0 Journal Article
%T AB249. 15-oxospiramilactone reverses multidrug resistance in the Human Renal Cell Carcinoma by targeting ABCB1 through Inhibition of Wnt/¦Â-catenin signaling
%J Archive of "Translational Andrology and Urology".
%D 2016
%R 10.21037/tau.2016.s249
%X Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for Human Renal Cell Carcinoma. P-glycoprotein ABCB1 plays a major role in MDR of malignant cells and is regulated by various transcription factors, including Wnt/¦Â-catenin /TCF4. We previously reported 15-oxospiramilactone was a new Wnt molecule inhibiter. In this study, ABCB1 was found to be significantly down regulated in A498 and ACHN cells by using 15-oxospiramilactone, suggesting an important role for the Wnt/b-catenin/TCF4 signaling pathway in cancer drug resistance
%K ABCB1
%K Wnt/¦Â-catenin signaling
%K 15-oxospiramilactone
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842754/