%0 Journal Article
%T Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells
%A Bianca J. Kuhn
%A Felix Hoppe-Seyler
%A Julia M£¿ndl
%A Karin Hoppe-Seyler
%A Svenja Adrian
%J Archive of "Viruses".
%D 2017
%R 10.3390/v9070174
%X Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (¡°hypoxia¡±), as present in sub-regions of HPV-positive cancers, strongly affect the interplay between the HPV oncogenes and their transformed host cell. As a result, a state of dormancy is induced in hypoxic HPV-positive cancer cells, which is characterized by a shutdown of viral oncogene expression and a proliferative arrest that can be reversed by reoxygenation. In this review, these findings are put into the context of the current concepts of both HPV-linked carcinogenesis and of the effects of hypoxia on tumor biology. Moreover, we discuss the consequences for the phenotype of HPV-positive cancer cells as well as for their clinical behavior and response towards established and prospective therapeutic strategies
%K human papillomavirus
%K hypoxia
%K cervical cancer
%K head and neck cancer
%K senescence
%K metabolism
%K mTOR
%K therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537666/