%0 Journal Article
%T SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
%A Alexandra Sch£¿fer
%A Dania M. Figueroa
%A Greg Saturday
%A Michael Letko
%A Neeltje van Doremalen
%A Patrick W. Hanley
%A Ralph S. Baric
%A Robert J. Fischer
%A Trenton Bushmaker
%A Vincent J. Munster
%A Vineet D. Menachery
%J Archive of "Viruses".
%D 2018
%R 10.3390/v10120727
%X Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats
%K WIV1-CoV
%K coronavirus
%K emerging infectious diseases
%K animal model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316779/