%0 Journal Article
%T TSC2 genetic variant and prognosis in nonİ\small cell lung cancer after curative surgery
%A Chang Ho Kim
%A Eung Bae Lee
%A Hyoİ\Gyoung Kang
%A Jae Yong Park
%A Jaehee Lee
%A Jang Hyuck Lee
%A Ji Yun Jeong
%A Jin Eun Choi
%A Kyung Min Shin
%A Mi Jeong Hong
%A Sanghoon Jheon
%A Seung Ick Cha
%A Seung Soo Yoo
%A Shin Yup Lee
%A Sook Kyung Do
%A Sukki Cho
%A Won Kee Lee
%A Yangki Seok
%A Yong Hoon Lee
%J Archive of "Thoracic Cancer".
%D 2019
%R 10.1111/1759-7714.12951
%X This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with nonİ\small cell lung cancer (NSCLC) after surgical resection. Twentyİ\three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and diseaseİ\free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21¨C2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15¨C2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, everİ\smokers, and stage I, but not in adenocarcinoma, neverİ\smokers, and stage II¨CIIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery
%K Lung cancer
%K polymorphism
%K prognosis
%K TSC2
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360237/