%0 Journal Article
%T New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems
%A Eric C. Ledbetter
%A Gerlinde R. Van de Walle
%A Matthew R. Pennington
%J Archive of "Viruses".
%D 2017
%R 10.3390/v9110349
%X Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models. Recent work has demonstrated the robustness and reproducibility of experimental ocular herpesvirus infections in dogs and cats, and, therefore, these non-traditional models can provide additional insights into the pathogenesis of ocular herpesvirus infections
%K herpesvirus
%K HSV-1
%K CHV-1
%K FHV-1
%K ocular infection
%K model systems
%K natural host infection
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707556/