%0 Journal Article
%T Protoparvovirus Interactions with the Cellular DNA Damage Response
%A David J. Pintel
%A Igor Etingov
%A Kinjal Majumder
%J Archive of "Viruses".
%D 2017
%R 10.3390/v9110323
%X Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection
%K MVM
%K DNA damage response
%K cell cycle
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707530/