%0 Journal Article
%T Clozapine-dependent inhibition of EGF/neuregulin receptor (ErbB) kinases
%A Eiko Kitayama
%A Hidekazu Sotoyama
%A Hiroyuki Nawa
%A Nobuyuki Takei
%A Toshiyuki Someya
%A Yuriko Iwakura
%A Yutaro Kobayashi
%J Archive of "Translational Psychiatry".
%D 2019
%R 10.1038/s41398-019-0519-1
%X Treatment with 0.1% DMSO (vehicle control), 30£¿¦ÌM olanzapine (OLZ), 30£¿¦ÌM clozapine (CLZ), 30£¿¦ÌM haloperidol (HAL), or 30£¿¦ÌM risperidone (RIS) for 48£¿h affected the proliferation/survival of U87MG cells (a) and A431 cells (b) grown in the normal growth medium. The number of living cells was estimated using the CCK-8 cell counting kit before and after the drug treatment. The graph reveals % ratio to the final cell number of control cultures treated with DMSO alone (mean£¿¡À£¿SE, n£¿=£¿6 sister cultures). Brown¨CForsythe test assessed the homogeneity of data variance in a (P£¿=£¿0.227), but not in b (P£¿=£¿0.075). One-way ANOVA followed by Tukey¡¯s test was applied to a; **P£¿<£¿0.01 and ***P£¿<£¿0.001 vs. control culture (DMSO). ¦Â£¿<£¿0.001 and ¦Ç2£¿=£¿0.799 for a. Multiple comparisons of Welch t-test with Bonferroni¡¯s compensation was performed with the given difference in data variance among groups in b; **P£¿<£¿0.01/4 and ***P£¿<£¿0.001/4 vs. control culture (DMSO). ¦Â£¿=£¿0.923, 0.000, 0.000, and 0.600; d£¿=£¿0.307, £¿4.662, £¿6.799, and £¿1.090 for OLZ, CLZ, HAL, and RIS vs. DMSO, respectivel
%K Pharmacology
%K Molecular neuroscience
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675791/