%0 Journal Article
%T Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis
%A Baki Akg¨¹l
%A Martin Hufbauer
%J Archive of "Viruses".
%D 2017
%R 10.3390/v9070187
%X Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (¦ÂHPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of ¦ÂHPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions. However, these assays failed to detect oncogenic functions of ¦ÂHPV early proteins. They were not suitable for investigations aiming to study the interactive role of ¦ÂHPV positive epidermis with mesenchymal cells and the extracellular matrix. This review focuses on ¦ÂHPV gene functions with special focus on oncogenic mechanisms that may be relevant for skin cancer development
%K betapapillomavirus
%K extracellular matrix
%K invasion
%K cancer initiating cells
%K wound healing
%K squamous cell carcinoma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537679/