%0 Journal Article
%T Case of advanced pulmonary squamous cell carcinoma cured by resection through preoperative induction of immune checkpoint inhibitor
%A Hideki Kawai
%A Hidesato Odaka
%A Hirokazu Kurokawa
%A Katsuhiko Enomoto
%A Kento Takahashi
%A Ryo Demura
%A Susumu Takahashi
%A Yoshitaro Saito
%J Archive of "Thoracic Cancer".
%D 2018
%R 10.1111/1759-7714.12592
%X The options for lung cancer treatment have increased due to the development of immune checkpoint inhibitors, but there has been no report of inoperable cases whereby the treatment effects rendered the case operable, an operation was subsequently performed, and histological assessment of the surgical specimen was carried out. Here, we report a 67©\year©\old man who was given pembrolizumab for T3N0 lung squamous cell carcinoma suspected of pericardial infiltration and judged inoperable. Treatment effect was evaluated after four courses. Computed tomography indicated a partial response, and operability was feasible. Therefore, thoracoscopic left upper lobectomy was performed after six courses of pembrolizumab, and histological assessment of the treatment effect was determined to be Ef 3, a complete response. The postoperative course was uneventful and he was discharged on the third postoperative day. We encountered a case that could be surgically treated after pembrolizumab administration. This treatment was safe and effective for advanced lung cancer
%K Immune checkpoint inhibitor
%K induction therapy
%K programmed death£¿1 inhibitors
%K squamous cell lung cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879048/