%0 Journal Article %T Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study %A Alexey Surov %A Anne Kathrin H£¿hn %A Hans Jonas Meyer %A Osama Sabri %A Sandra Purz %J Archive of "Translational Oncology". %D 2019 %R 10.1016/j.tranon.2018.08.018 %X BACKGROUND: Our purpose was to evaluate associations of combined 18F-FDG-PET and MRI parameters with histopathological features in head and neck squamous cell carcinoma (HNSCC). METHODS: Overall, 22 patients with HNSCC were acquired (10 with G1/2 tumors and 12 with G3 tumors).18F-FDG-PET/CT and MRI was performed and maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) were estimated. Neck MRI was obtained on a 3 T scanner. Diffusion weighted imaging was performed with estimation of apparent diffusion coefficient (ADC). Perfusion parameters Ktrans,Ve, and Kep were derived from dynamic contrast-enhanced (DCE) imaging. Different combined PET/MRI parameters were calculated as ratios: PET parameters divided by ADC or DCE MRI parameters. The following histopathological features were estimated: Ki 67, EGFR, VEGF, p53, hypoxia-inducible factor (HIF)-1¦Á, and cell count. Spearman's correlation coefficient (p) was used for correlation analysis. P < .05 was taken to indicate statistical significance. RESULTS: In overall sample, cellularity correlated with SUVmax/ADCmin (P£¿=£¿.558, P£¿=£¿.007), TLG/ADCmin (P£¿=£¿.546, P£¿=£¿.009), and MTV/ADCmin (P£¿=£¿.468, P£¿=£¿.028). MTV/Kep correlated with expression of HIF-1¦Á (P£¿=£¿.450, P£¿=£¿0,047). In G1/2 tumors, SUVmax/ADCmin correlated with HIF-1¦Á (P£¿=£¿£¿.648, P£¿=£¿.043); MTV/Kep (P£¿=£¿£¿.669, P£¿=£¿.034) and TLG/Kep (P£¿=£¿£¿.644, P£¿=£¿.044) with Ki67. In G3 tumors, cellularity correlated with SUVmax/ADCmin (P£¿=£¿.832, P£¿=£¿.001), SUVmax/ADCmean (P£¿=£¿.741, P£¿=£¿.006), and TLG/ADCmin (P£¿=£¿.678, P£¿=£¿.015). MTV/ADCmin and TLG/ADCmin tended to correlate with HIF-1¦Á. CONCLUSION: Combined parameters of 18F-FDG-PET and MRI can reflect Ki 67, tumor cellularity and expression of HIF-1¦Á in HNSCC. Associations between parameters of 18F-FDG-PET and MRI and histopathology depend on tumor grading %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143720/