%0 Journal Article %T Protein engineering approaches for antibody fragments: directed evolution and rational design approaches %A Dilara KARADA£¿ %A Merve ARSLAN %A Sibel KALYONCU %J Archive of "Turkish Journal of Biology". %D 2019 %R 10.3906/biy-1809-28 %K Antibody %K antibody fragment %K directed evolution %K rational design %K protein engineering %K phage display %K yeast surface display %K afinity %K biophysical properties %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426644/