%0 Journal Article
%T Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation
%A Alexej Abyzov
%A Brooke R. Druliner
%A Daniel O¡¯Brien
%A Donna Felmlee-Devine
%A Hongfang Liu
%A Jill Washechek-Aletto
%A Lisa A. Boardman
%A Nikolaos Vasmatzis
%A Nivedita Basu
%A Ruth Johnson
%A Shahrooz Rashtak
%A Taejeong Bae
%A Thomas Smyrk
%A Xiaoyang Ruan
%J Archive of "Translational Oncology".
%D 2016
%R 10.1016/j.tranon.2016.06.002
%X The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO +) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO + that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO £¿). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO + and RPO £¿ cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO + tumors were compared with that of age -and gender-matched CRC RPO £¿ evaluated by The Cancer Genome Atlas. CRC RPO + cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO £¿. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO £¿. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO + and RPO £¿ cases. Likewise, gene expression patterns are indistinguishable between the RPO + and RPO £¿ cases. We have confirmed that CRC RPO + is clinically and biologically similar to CRC RPO £¿ and may be utilized as a model of the adenoma to carcinoma transition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941582/