%0 Journal Article
%T Transcription infidelity and genome integrity: the parallax view
%A Alasdair J.E. Gordon
%A Christophe Herman
%A Jennifer A. Halliday
%A Priya Sivaramakrishnan
%J Archive of "Transcription".
%D 2018
%R 10.1080/21541264.2018.1491251
%X It was recently shown that removal of GreA, a transcription fidelity factor, enhances DNA break repair. This counterintuitive result, arising from unresolved backtracked RNA polymerase impeding DNA resection and thereby facilitating RecA-loading, leads to an interesting corollary: error-free full-length transcripts and broken chromosomes. Therefore, transcription fidelity may compromise genomic integrity
%K Transcription fidelity
%K DNA break repair
%K GreAB
%K DksA
%K RecBCD
%K Epimutation
%K Genomic integrity
%K Backtracked RNA polymerase
%K DNA resection
%K Genetic noise
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150618/