%0 Journal Article
%T Hexim1, an RNA-controlled protein hub
%A Annemieke A. Michels
%A Olivier Bensaude
%J Archive of "Transcription".
%D 2018
%R 10.1080/21541264.2018.1429836
%X Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). In addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets
%K CDK9
%K 7SK
%K NEAT1
%K P-TEFb
%K transcription regulation
%K innate immunity
%K melanoma
%K nucleotide depletion
%K eukaryotic transcription
%K transcriptional elongation
%K eukaryotic transcription
%K transcriptional elongation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104690/