%0 Journal Article
%T RNA polymerase I activation and hibernation: unique mechanisms for unique genes
%A Carlos Fern¨˘ndez-Tornero
%J Archive of "Transcription".
%D 2018
%R 10.1080/21541264.2017.1416267
%X In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA
%K ribosomal DNA
%K RNA polymerase I
%K transcriptional regulation
%K conformational state
%K enzyme activation
%K enzyme hibernation
%K cell growth
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104688/