%0 Journal Article
%T Orphan CpG islands as alternative promoters
%A Shrutii Sarda
%A Sridhar Hannenhalli
%J Archive of "Transcription".
%D 2018
%R 10.1080/21541264.2017.1373209
%X CpG islands (CGIs) are associated with กซ60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes
%K CpG islands
%K DNA methylation
%K alternative promoters
%K evolutionary selection
%K human
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927659/