%0 Journal Article
%T Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease
%A Jun-Juan Lu
%A Li Hua Xie
%A Qiang Zhang
%A Qing Wang
%A Sheng Hua Sun
%J Archive of "Tobacco Induced Diseases".
%D 2017
%R 10.1186/s12971-017-0148-5
%X Evaluation of COPD rat model. a Weight change of healthy control and COPD groups over the 90-day test period. At 30, 60 and 90 days, the weights of COPD rats were significantly lower than that of controls. n = 10, *P < 0.05,versus the control group. b Rat lung function. The PEF, FEV0.3 and FEV0.3/FVC values of COPD rats were also significantly reduced compared with controls. n = 10, *P < 0.05,versus the control group. c-f Hematoxylin and eosin staining of rat lung tissue (magnification, ¡Á100). c and d The lung tissue of control rats exhibited thin alveolar septa, normal alveoli and no inflammatory cell infiltration. e and f The lungs of COPD rats exhibited damaged alveolar septa, alveolar enlargement and inflammatory cell infiltration (indicated by black arrows). *P < 0.05. COPD, chronic obstructive pulmonary disorder; PEF, peak expiratory flow; FVC, forced vital capacity; FEV0.3, forced expiratory volume at 0.3
%K Chronic obstructive pulmonary disease
%K Quadriceps muscle atrophy
%K Fiber-type alteration
%K Tumor necrosis factor-like weak inducer of apoptosis
%K Muscle ring finger-1
%K Peroxisome proliferator-activated receptor-¦Ã coactivator-l¦Á
%K Nuclear factor-¦Ê B
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679159/