%0 Journal Article
%T The role of CYP3A5 polymorphism and dose adjustments following conversion of twice-daily to once-daily tacrolimus in renal transplant recipients
%A Alina S. R Zaltzman
%A G. V. Ramesh Prasad
%A Jeffrey S. Zaltzman
%A Lauren A. Glick
%A Michael Huang
%A Michelle Nash
%J Archive of "Transplantation Research".
%D 2016
%R 10.1186/s13737-016-0031-6
%X Tacrolimus is available as twice-daily Prograf£¿ (Tac-BID) and the once-daily formulation, Advagraf£¿ (Tac-OD). Although therapeutically equivalent, some transplant recipients require dose adjustments to achieve similar tacrolimus trough concentrations [Tac C0] after conversion between formulations. Tacrolimus is primarily metabolized by cytochrome P450 3A5 (CYP3A5). We sought to determine whether genetic polymorphisms in the CYP3A5 enzyme; CYP3A5 *1/*1 and CYP3A5 *1/*3 (expressers) compared to CYP3A5 *3/*3 (non-expressers) could account for discrepancies in dose requirements following conversion from Tac-BID to Tac-OD
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730664/