%0 Journal Article
%T The relationship between nicotine and psychosis
%A Harriet Quigley
%A James H. MacCabe
%J Archive of "Therapeutic Advances in Psychopharmacology".
%D 2019
%R 10.1177/2045125319859969
%X Cigarette smoking is strongly associated with psychotic disorders such as schizophrenia. For several decades it was assumed that the relationship could be explained by reverse causation; that smoking was secondary to the illness itself, either through self-medication or a process of institutionalization, or was entirely explained by confounding by cannabis use or social factors. However, studies have exposed that such hypotheses cannot fully explain the association, and more recently a bidirectional relationship has been proposed wherein cigarette smoking may be causally related to risk of psychosis, possibly via a shared genetic liability to smoking and psychosis. We review the evidence for these candidate explanations, using findings from the latest epidemiological, neuroimaging, genetic and preclinical work
%K nicotine
%K smoking psychosis
%K schizophrenia
%K psychotic disorder
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604123/