%0 Journal Article
%T Hypophosphatemia in the setting of metabolic bone disease: case reports and diagnostic algorithm
%A Alvin Lee Day
%A Kenneth G. Saag
%A Sarah L. Morgan
%J Archive of "Therapeutic Advances in Musculoskeletal Disease".
%D 2018
%R 10.1177/1759720X18779761
%X Osteoporosis is the most commonly encountered metabolic bone disease, and metabolic bone-disease clinics have been established to assist in the diagnosis and treatment of uncommon causes of low bone-mineral density. Hypophosphatemia leading to metabolic bone disease may be encountered, and an understanding of phosphate homeostasis can aid in the diagnosis. Two cases of hypophosphatemia leading to low bone-mineral densities were seen at the University of Alabama at Birmingham Osteoporosis Clinic. We developed a diagnostic algorithm, and the laboratory values of each patient were tested with the algorithm. The algorithm, incorporating the use of a spot urine phosphate and spot urine creatinine level at the time of initial serum metabolic profile evaluation, accurately determined the cause of hypophosphatemia in each case
%K diagnostic algorithm
%K hypophosphatemia
%K metabolic bone disease
%K osteomalacia
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047245/