%0 Journal Article
%T The monoclonal antibody GNbAC1: targeting human endogenous retroviruses in multiple sclerosis
%A Martin Diebold
%A Tobias Derfuss
%J Archive of "Therapeutic Advances in Neurological Disorders".
%D 2019
%R 10.1177/1756286419833574
%X Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS). Despite improvements of immunomodulatory therapies in relapsing¨Cremitting MS, the pathomechanisms of progressive disease are poorly understood and therapeutically addressed to date. A pathophysiological role for proteins encoded by human endogenous retroviruses (HERVs) has been proposed. GNbAC1 is a monoclonal antibody directed against the envelope protein of a HERV with postulated involvement in MS
%K relapsing multiple sclerosis
%K progressive multiple sclerosis
%K human endogenous retrovirus
%K monoclonal antibody
%K GNbAC1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407165/