%0 Journal Article
%T Advances in proton therapy in lung cancer
%A Charles B. Simone
%A II
%A Melissa A.L. Vyfhuis
%A Nasarachi Onyeuku
%A Neha P. Amin
%A Pranshu Mohindra
%A Shahed N. Badiyan
%A Sina Mossahebi
%A Tejan Diwanji
%J Archive of "Therapeutic Advances in Respiratory Disease".
%D 2018
%R 10.1177/1753466618783878
%X Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC
%K proton therapy
%K non-small cell lung cancer
%K pencil beam scanning
%K toxicities
%K radiation therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050808/