%0 Journal Article
%T High Flow Nasal Cannula, Is There a Role in COPD?
%J Archive of "Tanaffos".
%D 2017
%X High Flow Nasal Cannula refers to the delivery of gas intra-nasally via loose-fitting cannulae at flows up to 60 l/min and with FIO2 that can be varied between room air and 100%. The modality is generally well tolerated because the nasal cannulae are comfortable and the gas is heated and humidified to body temperature and saturation. In addition, it doesnĄ¯t interfere with speech or eating. Physiologically, it has a number of advantages over standard oxygen, including the humidification that enhances ciliary action and secretion removal, high inspiratory flow that cuts down on entrainment of room air, thus ensuring a more reliable delivery of a targeted FIO2, flushing out of upper airway dead space that improves efficiency of ventilation, reduction of respiratory rate that helps to cut down on work of breathing per minute, and a small amount of positive end expiratory pressure that may help to counterbalance auto-PEEP. In addition, it is clearly better tolerated than either standard mask oxygen delivery systems or noninvasive ventilation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684725/