%0 Journal Article %T The efficacy of adding budesonide/formoterol to ipratropium plus theophylline in managing severe chronic obstructive pulmonary disease: an open-label, randomized study in China %A Chen Wang %A Hongyang Wang %A Jian Kang %A Kewu Huang %A Li An %A Lijun Ma %A Liping Peng %A Rong Su %A Yanfei Guo %A Yohji Itoh %A Zeguang Zheng %J Archive of "Therapeutic Advances in Respiratory Disease". %D 2019 %R 10.1177/1753466619853500 %X Patients diagnosed with chronic obstructive pulmonary disease (COPD) in China are commonly prescribed ipratropium plus theophylline (I+T) therapy. Studies have shown that an inhaled corticosteroid (ICS)/long-acting ¦Â2-agonist (LABA) combination is also efficacious in reducing symptoms and exacerbations. This study evaluated the efficacy and tolerability of adding budesonide/formoterol (BUD/FORM) to I+T in Chinese patients with severe COPD %K antimuscarinic %K budesonide %K COPD %K formoterol %K glucocorticoid %K methylxanthine %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595664/