%0 Journal Article
%T 9- and 13-HODE regulate fatty acid binding protein-4 in human macrophages, but does not involve HODE/GPR132 axis in PPAR-¦Ã regulation of FABP4
%A Bernhard Baune
%A Catherine Rush
%A Fiona Collier
%A Jason Hodge
%A Richard Lee Kennedy
%A Usman Malabu
%A Venkat Vangaveti
%A Venkatesh Shashidhar
%J Archive of "Therapeutic Advances in Endocrinology and Metabolism".
%D 2018
%R 10.1177/2042018818759894
%X Both activation of monocytes and increased serum fatty acid binding protein-4 (FABP4) occur in diabetes and are associated with increased atherosclerosis. The oxidized lipid, 9-hydroxyoctadecadienoic acid (9-HODE) increases FABP4 in macrophages, and is a ligand for G protein-coupled receptor 132 (GPR132). We investigated the involvement of GPR132 in mediating the 9-, 13-HODE stimulation of FABP4 secretion, and whether GPR132 expression is increased in monocytes from patients with type 2 diabetes
%K FABP4
%K HODEs
%K macrophages
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958425/