%0 Journal Article %T Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis %A Armeen D. Poor %A Hooman D. Poor %J Archive of "Tanaffos". %D 2018 %X We report a case series of two patients in the intensive care unit with massive pulmonary embolism and obstructive shock who had resolution of shock after repeated administration of alteplase %K Acute pulmonary hypertension %K Alteplase %K Massive pulmonary embolism %K Obstructive shock %K Right ventricular failure %K Systemic thrombolysis %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320563/